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srebp 1c  (Boster Bio)


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    Boster Bio srebp 1c
    Srebp 1c, supplied by Boster Bio, used in various techniques. Bioz Stars score: 93/100, based on 10 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/srebp 1c/product/Boster Bio
    Average 93 stars, based on 10 article reviews
    srebp 1c - by Bioz Stars, 2026-02
    93/100 stars

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    Brusatol alleviates lipid dysregulation in IMQ-induced psoriatic mice by targeting IL-1β and subsequently activating the AMPK signaling pathway. A Representative western blots and B quantitative analysis of key proteins in the AMPK pathway in dorsal skin tissues from control (Con), model (Mod), and Brusatol-treated (Bru, 4.6 mg/kg) mice. Protein levels of total AMPKα, phosphorylated AMPKα (p-AMPKα), and downstream effectors for fatty acid oxidation (PPARα, CPT1A) and lipogenesis (SREBP-1, FASN, ACC1) were assessed, with β-actin as a loading control. C mRNA expression levels of Srebp-1c , Acc1 , Fasn , Pparα , and Cpt1a in dorsal skin tissues, as determined by RT-qPCR. Data in B and C are presented as mean ± SEM (n = 9 for ( B ); n = 5 for ( C )). * p < 0.05, ** p < 0.01, *** p < 0.001 vs . Mod group. # p <0.05 vs. control group.

    Journal: Chinese Medicine

    Article Title: Brusatol ameliorates psoriatic dyslipidemia by targeting IL-1β to restore AMPK-mediated lipid homeostasis

    doi: 10.1186/s13020-025-01287-8

    Figure Lengend Snippet: Brusatol alleviates lipid dysregulation in IMQ-induced psoriatic mice by targeting IL-1β and subsequently activating the AMPK signaling pathway. A Representative western blots and B quantitative analysis of key proteins in the AMPK pathway in dorsal skin tissues from control (Con), model (Mod), and Brusatol-treated (Bru, 4.6 mg/kg) mice. Protein levels of total AMPKα, phosphorylated AMPKα (p-AMPKα), and downstream effectors for fatty acid oxidation (PPARα, CPT1A) and lipogenesis (SREBP-1, FASN, ACC1) were assessed, with β-actin as a loading control. C mRNA expression levels of Srebp-1c , Acc1 , Fasn , Pparα , and Cpt1a in dorsal skin tissues, as determined by RT-qPCR. Data in B and C are presented as mean ± SEM (n = 9 for ( B ); n = 5 for ( C )). * p < 0.05, ** p < 0.01, *** p < 0.001 vs . Mod group. # p <0.05 vs. control group.

    Article Snippet: The primary antibodies including AMPKα (Rabbit, 66536–1-lg, Proteintech), p-AMPKα (Rabbit, 2535,CST), SREBP-1c (Rabbit, AF6288, Affinity), ACC1 (Rabbit, A19495, ABclonal), PPARα (Rabbit, 15540–1-AP, Proteintech), IL-1β (Rabbit, 16806–1-AP, Proteintech) and K17 (Rabbit, 13074, CST) were employed at a standardized dilution of 1:1000.

    Techniques: Western Blot, Control, Expressing, Quantitative RT-PCR